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| Evaluation of TGFB1 as candidate genes for high myopia in a Chinese population |
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作者：查屹 文章来源：温州医学院附属第二医院眼科 点击数：965 更新时间：2008/1/5 
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Purpose: to test the association between TGFB1 gene polymorphisms and high myopia in Hong Kong Chinese by using case-control association study
Methods: we enrolled 300 high myopic individuals (≤-8.0diopters) and 300 controls initially. SNPs chosen from TGFB1 gene were genotyped.
Results: 8 SNPs were identified in high myopia and controls, with four SNP(rs1800469,rs1982073,rs2241716 and rs4803455)having significant difference in allele and genotype frequencies between high myopia and unrelated control.
Conclusions: TGFB1 is a probable candidate gene for high myopia |
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| 会议投稿录入：毛进 责任编辑：毛进 |
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